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Trakia Journsl of Science, 2016, vol.14, n.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/116

Title: Effect of Staphylococcus Aureus infection on plasma creatine kinase activity in rabbits
Authors: Georgieva, T.
Petrov, V.
Lyutskanov, M.
Georgiev, I.
Zaprianova, D.
Marutsov, P.
Rusenova, N.
Parvanov, P.
Keywords: rabbits
Staphylococcus aureus
inflammation
creatine kinase
abscess
fibrinogen
Issue Date: 2016
Citation: T. Georgieva, V. Petrov, M. Lyutskanov, I. Georgiev, D. Zaprianova, P. Marutsov, N. Rusenova and P. Parvanov. Effect of Staphylococcus Aureus infection on plasma creatine kinase activity in rabbits, 14, 2016, N 1, 52-59
Abstract: The aim of the present study was to investigate the variations of the plasma creatine kinase (CK) activities following an experimentally induced staphylococcal infection in rabbits and to compare them with the occurrence of clinical signs. For that, the plasma CK activities were determined in 7 male New Zealand White, 3 months old rabbits subcutaneously injected with Staphylococcus aureus strain suspension (density: 8х108 cfu/mL) and in 6 other rabbits not treated (controls). In parallel, rectal temperature and skin lesions (abscesses) were recorded. In all infected animals, formation of abscess due to the proliferation of the inoculated strain was observed within 48-96 hours following the bacterial inoculation and these lesions have gradually extended leading to purulent exudates several days after and sometimes to secondary abscesses in surrounding muscles. The concentration of fibrinogen was used as an acute phase protein with aim to confirm the incidence of infection. Plasma CK activities were dramatically elevated on 48 hour compared to initial values and to controls at the same time but this increase was transient, the CK activities being similar to controls since the 72nd hour. These results indicate that the plasma CK activity in rabbit can be considered as a precocious marker of skin and secondary muscular damage related to the abscess formation and probably to the bacterial exotoxins following experimental staphylococcal infection.
URI: http://hdl.handle.net/123456789/116
ISSN: 1313-3551
Appears in Collections:Trakia Journsl of Science, 2016, vol.14, n.1

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