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Trakia Journsl of Science, 2016, vol.14, n.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/117

Title: Oropharyngeal candidiasis and antifungal assessment of Candida glabrata in patients with HIV infection
Authors: Sharifzadeh, A.
Shokri, H.
Keywords: oral cavity
Candida glabrata
HIV infection
amphotericin B
Issue Date: 2016
Citation: A. Sharifzadeh and H. Shokri. Oropharyngeal candidiasis and antifungal assessment of Candida glabrata in patients with HIV infection, 14, 2016, N 1, 60-66
Abstract: The purposes of this study were to determine the prevalence of oral mycoflora in HIV+ patients and to assay antifungal susceptibility profile of Candida glabrata (C. glabrata) isolates to standard antifungal agents. A total of 100 HIV-infected patients with oropharyngeal candidiasis (OPC) were selected in this study. Susceptibility of C. glabrata isolates to antifungals was determined using the disc diffusion method. A total of 254 yeasts were isolated from the patients. Forty percent (40%) of the patients had angular cheilitis as the most frequent clinical variant. Candida species (94.4%) were the most frequently obtained genera (P<0.05), followed by Saccharomyces (2.4%), Kluyveromyces and Cryptococcus (1.6%) species. C. albicans (37.2%) was the most common species isolated from HIV+ patients with OPC and its frequency was significantly higher than that of other Candida species (P<0.05). Among non-C. albicans species, C. glabrata was the most frequent species. Highest sensitivity of C. glabrata to antifungal drugs was seen against polyene drugs such as nystatin and amphotericin B. This study revealed huge diversity of Candida species and oral isolates of C. glabrata were most sensitive to polyene drugs such as nystatin and amphotericin B and least sensitive to fluconazole.
URI: http://hdl.handle.net/123456789/117
ISSN: 1313-3551
Appears in Collections:Trakia Journsl of Science, 2016, vol.14, n.1

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